Mebendazole

vermox-tablet

What is Mebendazole

Mebendazole (brand name: Vermox) is a broad-spectrum anthelmintic prescribed for the treatment roundworm and tapeworm infections. Mebendazole kills parasites (worms) in the digestive tract by inhibiting the metabolism inf the parasite’s body. Mebendazole is not over the counter medication (not available without a prescription).

Indications

Mebendazole is prescribed to treat:
  • helminthiasis (macroparasitic disease of humans and animals in which a part of the body is infected with parasitic worms – tapeworms, flukes, and roundworms);
  • ancylostomiasis (disease caused by large number of hookworms, producing an iron deficiency anemia by sucking blood from the host’s intestinal walls);
  • strongyloidiasis (parasitic disease caused by the nematode (roundworm) leading to principally skin symptoms, abdominal pain, diarrhea and weight loss and even death in patients who needs immunosuppressive medication if left untreated);
  • trichuriasis (worm infection in the tissue of the cecum, appendix, colon and rectum caused by whipworm Trichuris trichiura and intestinal parasitic nematode);
  • echinococcosis (parasitic disease that affects both humans and other mammals that has a significantly high fatality rate);
  • taeniasis (infection which is caused by the pork tapeworms Taenia solium and the beef tapeworm Taenia saginata that absorb most of the digested food and the host becomes terribly weak);
  • alveococcosis (serious chronic disease of progressive flow characterised by development in a liver solitary or plural parasitogenic cystic formations);
  • capillariasis (infection caused by nematodes in the Capillaria genus);
  • trichinosis (helminth infection caused by of roundworm Trichinella spiralis when eating raw or undercooked pork or wild game infected with the parasite);
  • mixed helminth infections (infections caused by more than one type of helminth).

Mechanism of action

Mebendazole selectively affects cytoplasmic microtubules of helmintрs, inhibits the uptake of glucose and the formation of ATP in their body. The same in simple words – Mebendazole disrupts the metabolism in the body of a helminth (worm) preventing the absorption of sugar (glucose) and as a result causes death of the parasite. Mebendazole is also influences by inhibiting the development of worms’ eggs.

Important information

You should not take Mebendazole in the cases of hypersensitivity, ulcerative colitis, Crohn’s disease, liver failure. Children aged under 2 years, women during pregnancy and lactation should avoid Mebendazole therapy.

Dosages and administration

Mebendazole (Vermox) tablets are administrated orally with a small amount of water.For enterobioze: –        adults and children over 10 years –  single dose 100 mg. –        children aged 2 – 10 years – one dose 25-50mg. In the case of a high probability of re-infestation repeat the same dosages after 2-4 weeks. It is recommended to lead concurrent treatment of all family members. For ascariasis, trihotsefaleze, hookworm, teniasis, strongyloidiasis and mixed helminthiasis: – twice a day 100 mg of Mebendazole for 3 days. For trichinosis take Mebendazole 3 times a day 200-400mg (2-3 tablets at once) for 3 days, and the next 4 – 10 days – 3 times a day and increase the single dose up to 400-500mg (4-5 tablets at once). For echinococcosis: – the first 3 days – 500 mg single dose 2 times a day. For the next 3 days the dose is increased up to 500 mg three times a day. Further the dosage should be increased to the maximum and received every 3-4 hours. Maximum dosage – 25-30 mg / kg / day.

If you missed a dose

Take the missed dose as soon as possible unless it is almost due time for your next dose. In this case you should skip missed dose. Do not take extra capsule to make up the missed dose.

Drug Interaction

The expected effect of treatment may change if Mebendazole is used in combination with other medicines. The intention to use of other drugs with mebendazole should be discussed with your doctor. Do not drink alcohol during treatment, or in the day after its completion.

Side effects

The most common side effects are: dizziness, nausea, and abdominal pain. When used in high dosages for a long time: vomiting, diarrhea, headache, allergic reactions (rash, angioedema), hair loss, hepatitis, increased activity of “liver” transaminases, hypercreatininemia, leukopenia, anemia, neutropenia, eosinophilia, hematuria, cylindruria. Mebendazole can have a negative impact on the development of the fetus.

Generic Vermox

There are several versions of generic Vermox are available on the market.